Magnesium is the second most abundant intracellular mineral needed as a cofactor in over 300 enzymatic reactions in the body. It is an essential mineral for various biochemical and metabolic pathways, including cellular energy production, protein synthesis, gene regulation, maintenance of healthy bones and teeth, as well as for proper brain and nervous system function. However, not all forms of magnesium have the same properties.
One of the latest and most researched forms is magnesium L-threonate, patented as Magtein®, which you can find in our new supplement, ThreoMag.
Article at a glanc:
- What is Magnesium L-Threonate?
- What are the Benefits of Magnesium L-Threonate?
- Who is ThreoMag Suitable For
- How to Use ThreoMag?
What is Magnesium L-Threonate?
Magnesium L-threonate is a specific form of magnesium that combines magnesium with L-threonate acid (a metabolite of ascorbic acid, or vitamin C). This unique chemical structure allows magnesium to cross the blood-brain barrier, which is the protective barrier between the bloodstream and the brain. Most forms of magnesium have limited ability to cross this barrier, but studies show that magnesium L-threonate can effectively increase magnesium levels directly in the brain. [1]
Magtein® is currently the only patented and scientifically validated version of this form of magnesium, guaranteeing quality, purity, and effectiveness.
What are the Benefits of Magnesium L-Threonate?
In 2010, a study published in the prestigious journal Neuron demonstrated that the compound magnesium L-threonate (Magtein®) can effectively enter brain cells. [1] According to this study conducted on rodent models, magnesium L-threonate (Magtein®) has higher bioavailability compared to other magnesium supplements, can increase magnesium levels in the cerebrospinal fluid, and improve synaptic plasticity (the brain's ability to form and strengthen nerve connections), leading to significant improvements in memory and learning.
Research also indicates that magnesium L-threonate may help slow cognitive decline associated with aging. In 2016, a randomized, double-blind, placebo-controlled study involving older American adults (aged 50 to 70) [2] confirmed that supplementation with magnesium L-threonate significantly improved overall cognitive scores compared to placebo.
Further studies demonstrate that Magtein exhibits neuroprotective effects, which may be useful in protecting the brain from neurodegenerative diseases. Research on a mouse model [3] showed that supplementation with L-threonate could benefit patients with Parkinson's disease. By increasing magnesium levels in the cerebrospinal fluid, there was a reduction in the loss of dopamine receptors and improvement in motor function.
Magnesium supplementation may also improve symptoms of migraines, Alzheimer’s disease, cardiovascular diseases, type 2 diabetes, and help with anxiety in individuals prone to psychological stress. Higher magnesium intake is also associated with lower symptoms of depression. [4] [5]
Who is ThreoMag Suitable For
ThreoMag is particularly suitable for older individuals who want to support cognitive functions and maintain healthy memory, as well as for people exposed to stress and intense mental performance. It can help improve concentration, memory, and reduce anxiety and stress.
ThreoMag can generally be recommended for anyone looking to support brain function while also benefiting from other advantages of magnesium, such as supporting the nervous system, alleviating anxiety, or improving sleep quality.
How to Use ThreoMag?
If you are looking for a way to support your memory, concentration, and overall cognitive performance, magnesium L-threonate can be a very useful tool. For optimal support of brain functions, regular and long-term use is recommended. The typical recommended dose of Magtein is usually 2000 mg per day. Therefore, it is advisable to take ThreoMag in a basic dose of 3 capsules daily, and if necessary, the dose can be increased up to double, i.e., 4000 mg per day, or 6 capsules daily. You can take it with food.
Proper timing is also important, as this form of magnesium may be problematic for some individuals, especially if taken in the evening before sleep. Magnesium threonate can support higher brain activity, which may keep some people in a state of unwanted alertness, especially if they take the dose late in the evening. It is necessary to test individual responses and adjust the dosing scheme accordingly.
It is generally recommended to take magnesium in the evening on an empty stomach before sleep; however, ThreoMag is a specific form of magnesium that may not suit everyone in the evening. If ThreoMag disrupts your sleep architecture (e.g., causing nighttime awakenings or shortening sleep), we recommend moving the evening dose to late afternoon (around 4-5 PM), or completely skipping the evening dose and timing ThreoMag for the morning and afternoon to support cognitive abilities. Dividing the total daily dose into morning and afternoon can help avoid sleep disruption while retaining Magtein's cognitive benefits.
Sources:
[1] Slutsky I, Abumaria N, Wu LJ, Huang C, Zhang L, Li B, Zhao X, Govindarajan A, Zhao MG, Zhuo M, Tonegawa S, Liu G. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010 Jan 28;65(2):165-77. doi: 10.1016/j.neuron.2009.12.026. PMID: 20152124.
[2] Liu G, Weinger JG, Lu ZL, Xue F, Sadeghpour S. Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Alzheimers Dis. 2016;49(4):971-90. doi: 10.3233/JAD-150538. PMID: 26519439; PMCID: PMC4927823.
[3] Shen Y, Dai L, Tian H, Xu R, Li F, Li Z, Zhou J, Wang L, Dong J, Sun L. Treatment Of Magnesium-L-Threonate Elevates The Magnesium Level In The Cerebrospinal Fluid And Attenuates Motor Deficits And Dopamine Neuron Loss In A Mouse Model Of Parkinson's disease. Neuropsychiatr Dis Treat. 2019 Nov 11;15:3143-3153. doi: 10.2147/NDT.S230688. PMID: 31806980; PMCID: PMC6857673.
[4] Volpe SL. Magnesium in disease prevention and overall health. Adv Nutr. 2013 May 1;4(3):378S-83S. doi: 10.3945/an.112.003483. PMID: 23674807; PMCID: PMC3650510.
[5] Boyle NB, Lawton CL, Dye L. The effects of magnesium supplementation on subjective anxiety. Magnes Res. 2016 Mar 1;29(3):120-125. English. doi: 10.1684/mrh.2016.0411. PMID: 27869100.
